US Patent:
20110178097, Jul 21, 2011
Inventors:
Augustus O. Okhamafe - Concord CA, US
Joyce Chou - El Cerrito CA, US
Rampurna Gullapalli - San Bruno CA, US
Eric Harwood - Seattle WA, US
David Ryckman - San Diego CA, US
Shuguang Zhu - San Diego CA, US
Xiao Shang - Bellevue WA, US
Assignee:
NOVARTIS AG - Emeryville CA
International Classification:
C07D 401/14
A61K 31/496
A61P 35/04
Abstract:
The present invention relates to non-hydrate crystalline forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts, solid pharmaceutical formulations containing the same and methods of use. The present invention also relates to crystalline hydrates of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts, pharmaceutical formulations containing the same and methods of use related thereto. The present invention further relates to crystalline solvates of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts.