Inventors:
Laszlo Takacs - Newbury Park CA, US
Andras Guttman - San Diego CA, US
William S. Hancock - Brookline MA, US
Barry L. Karger - Newton MA, US
Manuel Duval - New London CT, US
Patrick Berna - Gaillon, FR
Assignee:
Northwestern University - Boston MA
International Classification:
G01N 33/53
US Classification:
435 71, 436538, 436548, 514 11
Abstract:
A method or platform for monoclonal antibody based biomarker discovery is disclosed. The method according to the invention provides for the integration of analyte collection, hybridoma screening and nanovolume integrated mass spectrometry (NVIMS) to achieve a robust screening system that is capable, for example, of cutting 4-6 years off of the classical biomarker discovery and development process. The invention provides a platform for the rapid, high-throughput production, isolation and characterization of, e. g. , disease specific biomarkers together with highly specific monoclonal antibodies. The method of the invention has a variety of applications such as, but not limited to, drug testing, biohazard applications, ecological applications, physiological applications and/or pathology screening applications. The method of the invention is also capable of being performed or used as or with a high-throughput screening process or system of the invention.
