Inventors:
James M. Ervasti - Shoreview MN, US
Kevin J. Sonnemann - Minneapolis MN, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07K 19/00
C12N 15/62
US Classification:
435 697, 514 165, 530350, 536 234
Abstract:
Disclosed is a fusion protein including a full-length TAT-utrophin or an anti-dystrophinopathic fragment thereof, a method of treating dystrophinopathies (including Duchenne muscular dystrophy) using the fusion protein, a pharmaceutical composition for treating dystrophinopathies in mammals comprising the fusion protein, and nucleic acid constructs for expressing the fusion protein.