US Patent:
20140161720, Jun 12, 2014
Inventors:
Igor Garkavtsev - Cambridge MA, US
Rakesh K. Jain - Wellesley MA, US
Assignee:
THE GENERAL HOSPITAL CORPORATION - Boston MA
International Classification:
C07D 311/92
A61K 36/185
A61K 31/352
A61K 45/06
A61K 47/30
US Classification:
424 111, 424450, 514454, 514455
Abstract:
Described herein are methods and compositions comprising a compound of formula (I), e.g., dehydro-alpha-lapachone, or an analog, derivative, isomer, prodrug, or pharmaceutically acceptable salt thereof, for treatment and/or prevention of angiogenic- or vascular-associated diseases or disorders. The compound has anti-vascular activity. In some embodiments, the compound has anti-vascular activity that targets pathways other than VEGF pathways. In some embodiments, the compound or the composition further comprises anti-tumor activity. In some embodiments, the compound or the composition can decrease adhesion or motility of at least one cell (e.g., endothelial cells or cancer cells).
