Evgenia Razumovski

20110224104, Sep 15, 2011

Jun 1, 2007

11/757020

Evgenia Razumovski - Columbia MD, US
Berk Oktem - Columbia MD, US
Appavu K. Sundaram - Montgomery Village MD, US
Vsevolod S. Rakov - New Haven CT, US
Sudeepta Shanbhag - Ellicott City MD, US
Sergey Kurnosenko - Fairfax VA, US
Vladimir M. Doroshenko - Ellicott City MD, US

Science & Engineering Services, Inc. - Columbia MD

C40B 50/06
C12Q 1/04
C12M 1/34
C40B 60/14

506 26, 435 34, 4352871, 506 40

A method and system for identification of microorganisms in a sample. The method includes processing the sample to produce at least one group of biomarker molecules from at least one microorganism in the sample, tandem mass-analyzing biomarker fragment ions from the at least one group of biomarker molecules to obtain a sample biomarker tandem mass spectrum of the biomarker, and identifying the microorganism in the sample based on a comparison of the sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum (stored in the reference library) from a known microorganism. The system includes a sample processing unit configured to process the sample and produce at least one group of biomarker molecules from at least one microorganism in the sample. The system includes a mass-analyzer for tandem mass analysis biomarker fragment ions. The system includes a processor configured to identify the microorganism in the sample based on a comparison of a sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum from a known microorganism.

20180240659, Aug 23, 2018

Feb 23, 2017

15/441066

- Bremen, DE
Hans PFAFF - Ganderkesee, DE
Evgenia RAZUMOVSKI - San Diego CA, US

H01J 49/00
H01J 49/34
G01N 30/86
G01N 30/72

Methods of identification of at least one most likely elemental composition of at least one species of molecules contained in a sample and/or originated from a sample by at least one ionisation process are provided. The method includes measuring a mass spectrum of the sample and may include reducing the measured mass spectrum to a neutral mass spectrum. The method further includes determining for a peak of interest a set of candidate species of molecules which have an expected peak with a peak position within a peak position tolerance range in the corresponding measured mass spectrum or neutral mass spectrum. An identification mass spectrum is identified for each candidate species and a range of peak positions is determined of all peaks of the identification mass spectrum. Two subscores of candidate species are determined by comparing the identification spectra with the measured or neutral mass spectrum and final scores are calculated from the subscores. An elemental composition of the candidate species is determined having calculated final scores of the highest values.