Dorothy M Morre

20020176897, Nov 28, 2002

Mar 19, 2002

10/102502

Dorothy Morre - West Lafayette IN, US
D. Morre - West Lafayette IN, US

Purdue Research Foundation

A61K035/78

424/729000

The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds.

20020176898, Nov 28, 2002

Apr 3, 2002

10/114998

Dorothy Morre - West Lafayette IN, US
D. Morre - West Lafayette IN, US
Raymond Cooper - Mountain View CA, US
Michael Chang - Brisbane CA, US

Purdue Research

A61K035/78
A61K031/7048

424/729000, 514/027000

The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a sustained release formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.

20030072821, Apr 17, 2003

Feb 22, 2002

10/081903

Dorothy Morre - West Lafayette IN, US
D. Morre - West Lafayette IN, US

A61K035/78
A61K031/16

424/729000, 424/760000, 514/625000

The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of catechins and vanilloids. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). In a preferred embodiment the catechins have been treated with tannase. Compositions of vanilloids include, but are not limited to vanillylamine, the head group of capsaicin. The unique compositions of the invention contain various combinations of the catechins and vanilloids, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses various modes of administration of the therapeutic compounds, including formulations which may be used as a dietary or nutritional supplement or as a therapeutic compound.

20030170757, Sep 11, 2003

Feb 24, 2003

10/373579

D. Morre - West Lafayette IN, US
NaMi McCarty - Cambridge MA, US
Dorothy Morre - West Lafayette IN, US
Pin-Ju Chueh - West Lafayette IN, US

G01N033/574
C07K016/40

435/007230, 530/388260

Compositions and methods for diagnosis of neoplastic tissue are described. Monoclonal antibodies which specifically recognize the tumor cell specific NADH:protein thiol reductase and the hybridoma cell lines which produce them are provided. Also provided are diagnostic and immunohistological assays for the identification of cells that are neoplastic. Because the antibodies specifically prevent the growth of cancer cells, induce apoptotic cell death of cancer cells, and are without effect on normal cells, the described monoclonal antibodies are useful for inhibiting cancer cell growth and for treating a neoplastic condition.

20030207340, Nov 6, 2003

May 1, 2002

10/138195

D. Morre - West Lafayette IN, US
Dorothy Morre - West Lafayette IN, US
Pin-ju Chueh - West Lafayette IN, US

C12Q001/68
G01N033/574
C07H021/04
C12N009/02
C12P021/02
C12N001/21
C12N005/06

435/007230, 435/006000, 435/069100, 435/189000, 435/320100, 435/252330, 435/358000, 536/023200

The present disclosure provides the nucleotide sequence encoding a cell surface NADH oxidase/protein disulfide-thiol interchange protein (tNOX) characteristic of neoplastic and virus-infected cells. Also provided are recombinant DNA molecules comprising a sequence portion encoding full length or truncated tNOX, recombinant host cell which express full length or truncated tNOX, methods for recombinant production of tNOX or truncated tNOX, and diagnostic methods which employ either nucleotide sequences of the neoplastic cell-specific tNOX or antibodies specific for the rNOX protein.

20040142048, Jul 22, 2004

Feb 11, 2004

10/468911

Dorothy Morre - West Lafayette IN, US
D Morre - West Lafayette IN, US

A61K035/78
A61K031/7048
A61K031/353

424/729000, 514/027000, 514/456000

The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of catechins and proanthocyanadins. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). Compositions of proantho-cyanains include, but are not limited to, blue fruit extracts. The unique compositions of the invention contain various combinations of the catechins and proanthocyanadins, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses various modes of administration of the therapeutic compounds, including formulations which may be used as a dietary or nutritional supplement or as a therapeutic compound.

20050031716, Feb 10, 2005

Jul 6, 2004

10/886159

D. Morre - West Lafayette IN, US
Dorothy Morre - West Lafayette IN, US

A61K035/78
A61K031/16

424760000, 514629000

The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of therapeutically effective amount of catechins, a group of polyphenols found in green tea, and extracts. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins and extracts, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.

20050169903, Aug 4, 2005

Feb 11, 2005

11/056011

Dorothy Morre - West Lafayette IN, US
D. Morre - West Lafayette IN, US

A61K038/43
A61K031/12

424094100, 514690000

The invention described herein encompasses methods of preventing or treating disorders caused by oxidative damage by an aging-specific isoform of NADH oxidase (AR—NOX). The invention encompasses methods of assaying, screening, and identifying agents that inhibit AR—NOX, as well as methods using ubiquinone to inhibit the ability of AR—NOX to generate reactive oxygen species. These agents may be formulated into pharmaceutical compositions in the prevention and treatment of disorders caused by oxidative damage.