Inventors:
Timothy R. Hurley - Ypsilanti MI
Dino A. Sherwood - Taylor MI
Peter W. K. Woo - Ann Arbor MI
Karl-Otto Vollmer - Freiburg, DE
Egmont Schaller - Heuweiler, DE
Wolfgang Klemisch - Freiburg, DE
Albrecht V. Hodenberg - Kenzingen, DE
Assignee:
Warner-Lambert Co. - Morris Plains NJ
International Classification:
A61K 3144
C07D40106
C07D21170
Abstract:
The present invention relates to the + or - pirmenol stereoisomers and to selected metabolites of pirmenol or (+,-)-cis-. alpha. -[3-(2,6-dimethyl-1-piperidinyl))propyl]-. alpha. -phenyl-2 -pyridinemethanol which are active as antiarrhythmic agents. The pharmacological use of the metabolites that is the present invention is as antiarrhythmic agents. Pharmaceutical compositions comprising the metabolites are also within the scope of the invention.