Inventors:
Robert Adolfsen - Montrose NY, US
Nicolae Dumitrescu - Stamford CT, US
Michael Avdenko - Rochester NY, US
Dario Svenjak - Yorktown Heights NY, US
Assignee:
Siemens Healthcare Diagnostics Inc. - Tarrytown NY
International Classification:
C12Q 1/68
C12M 1/34
Abstract:
A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends the NA in elution buffer solution. The PCR testing apparatus provides multiple cycles of the denaturing, annealing, and elongating thermal cycles. More particularly, the PCR testing apparatus includes a multi-vessel thermal cycler array that has a plurality of single-vessel thermal cyclers that is each individually-thermally-controllable so that adjacent single-vessel thermal cyclers can be heated or cooled to different temperatures corresponding to the different thermal cycles of the respective PCR testing process.
