Daniel K Lathrop

7365536, Apr 29, 2008

May 10, 2005

11/125646

Christopher Crowley - San Diego CA, US
Daniel K. Lathrop - San Diego CA, US

General Electric Company - Schenectady NY

G01V 3/00

324300, 324307

An inspection system includes an electromagnetic shield having electrically conductive sidewalls spaced from one another. The shield also includes a conductive third wall which spans the distance between the sidewalls, and is electrically coupled to the sidewalls. The inspection system also has an inductive sensor positioned within the electromagnetic shield. The inductive sensor has two current branches, which exhibit anti-symmetric current flow. Typically, the two current branches are positioned on opposing sides of the medial plane of the electromagnetic shield.

8283157, Oct 9, 2012

Jun 18, 2009

12/999157

Andrew D Hibbs - La Jolla CA, US
Geoffrey Alden Barrall - San Diego CA, US
Eric N Ervin - Park City UT, US
Daniel K Lathrop - San Diego CA, US

Electronics Biosciences, Inc. - San Diego CA

C12M 1/00

4352872, 204451, 204601

An electrolytic system includes an analyte chamber having an access port for introducing a sample containing a molecules of interest, such as DNA. Electrodes create an electric field along a length of the analyte chamber to drive molecules toward an interaction region containing a nanopore, thereby increasing the arrival rate of molecules at the nanopore. Additional electrodes may be utilized to create an electric field through the nanopore to drive a molecule into the nanopore. A current sensor may be utilized to count, discriminate or characterize the molecules as they interact with the nanopore. Advantageously, system can be utilized for unamplified DNA sequencing.

8452546, May 28, 2013

Nov 9, 2009

12/614782

Daniel K Lathrop - San Diego CA, US

Electronic Biosciences, Inc. - San Diego CA

G06F 19/00
C12Q 1/68

702 20, 435 61

A method of processing sequencing data obtained with a polymer sequencing system identifies the most likely monomer sequence of a polymer, regardless of stochastic variations in recorded signals. Polymer sequencing data is recorded and two or more distinct series of pore blocking signals for a section of the polymer are recorded. A value is assigned to each series of pore blocking signals to obtain multiple trial sequences. The probability that each of the trial sequences could have resulting in all of trial sequences is calculated to determine a monomer sequence with the highest probability of resulting in all of the trial sequences, termed the first iteration sequence. The first iteration sequence is systematically altered to maximize the combined probability of the first iteration sequence leading to all the trial sequences in order to obtain a most likely sequence of monomers of the polymer.

20090222216, Sep 3, 2009

Mar 1, 2009

12/395682

Andrew D. Hibbs - La Jolla CA, US
Geoffrey Alden Barrall - San Diego CA, US
Daniel K. Lathrop - San Diego CA, US

Electronic Bio Sciences, LLC - San Diego CA

G06F 19/00
G01R 33/48

702 20

The sequencing of individual monomers (e.g., a single nucleotide) of a polymer (e.g., DNA, RNA) is improved by reducing the motion of the polymer due to thermally-driven diffusion to reduce the spatial error in the position of the polymer within a measurement device. A major system parameter, such as average translocation velocity or measurement time, is selected based on the characteristics of the sensing system utilized, and an algorithm jointly optimizes the sequencing order error rate and the monomer identification error rate of the system.

20120310543, Dec 6, 2012

Jun 29, 2012

13/538537

Andrew D. Hibbs - La Jolla CA, US
Geoffrey Alden Barrall - San Diego CA, US
Daniel K. Lathrop - San Diego CA, US

ELECTRONIC BIO SCIENCES, LLC - San Diego CA

G06F 19/10

702 20

The sequencing of individual monomers (e.g., a single nucleotide) of a polymer (e.g., DNA, RNA) is improved by reducing the motion of the polymer due to thermally-driven diffusion to reduce the spatial error in the position of the polymer within a measurement device. A major system parameter, such as average translocation velocity or measurement time, is selected based on the characteristics of the sensing system utilized, and an algorithm jointly optimizes the sequencing order error rate and the monomer identification error rate of the system.

20210396132, Dec 23, 2021

Dec 13, 2019

17/289409

- San Diego CA, US
Joseph M. PENDLETON - Temecula CA, US
Stacy J. KOUBA - San Diego CA, US
Daniel LATHROP - San Diego CA, US
Igor FRIDMAN - Rockville MD, US

E21B 47/13
G01V 3/38

Techniques to improve the measurement of electromagnetic fields based on noise cancellation are disclosed. Sensors placed at the earth's surface measure electromagnetic fields emanating from within the earth, and/or perform electromagnetic telemetry. In one embodiment, signal processing techniques are applied to the acquired signals, either in real time or near real time to reduce or cancel the noise to enable the signal of interest to be measured. In another embodiment, the location of the plurality of sensors is judiciously chosen to improve the measurement of the signal of interest.