Allan Spradling Phones & Addresses
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1810 Circle Rd, Towson, MD 21204 (410) 821-1607
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1818 Circle Rd, Towson, MD 21204 (410) 821-1607
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1818A Circle Rd APT A, Towson, MD 21204 (410) 821-1607
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1818A Circle Rd, Towson, MD 21204
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Baltimore, MD
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Westminster, MD
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Ocean City, MD
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Greenville, SC
Business Records
Name / Title
Company / Classification
Phones & Addresses
Principal
Carnegie Institution of Washington
Commercial Physical Research · Noncommercial Research Organization Commercial Physical Research
Commercial Physical Research · Noncommercial Research Organization Commercial Physical Research
3520 San Martin Dr, Baltimore, MD 21218
(410) 467-1414, (410) 243-6311
(410) 467-1414, (410) 243-6311
Publications
Amazon
Evolutionary Conservation of Developmental Mechanisms: 50th Symposium of the Society for Developmental Biology
An overview of the fundamental mechanisms of multicellular development, focusing on unifying themes in the study of developmental biology. Topics discussed include the role of highly conserved transcription factors in embryonic patterning, generation of distinct germline and soma, transmission and i...
Author
Allan C. Spradling
Binding
Hardcover
Pages
238
Publisher
Wiley
ISBN #
0471588431
EAN Code
9780471588436
ISBN #
3
[ Howard Hughes Medical Investigators: Allan C. Spradling, Angelika Amon, Arthur L. Horwich, Arul Chinnaiyan, Atul Butte, Axel T. Brunger, Barbara J. Me Source Wikipedia ( Author ) ] { Paperback } 2013
[ Howard Hughes Medical Investigators: Allan C. Spradling, Angelika Amon, Arthur L. Horwich, Arul Chinnaiyan, Atul Butte, Axel T. Brunger, Barbara J. Me Source Wikipedia ( Author ) ] { Paperback } 2013
Author
Source Wikipedia
Binding
Paperback
Publisher
University-Press.Org 2013
ISBN #
4
GENETIC TRANSFORMATION OF DROSOPHILA WITH TRANSPOSABLE ELEMENT VECTORS. (Pioneer work on the use of artificial P elements to insert genes into Drosophila--a Forerunner of Gene Therapy).
Author
Gerald M. and Allan C. Spradling. RUBIN
Binding
Paperback
Publisher
American Association for the Advancement of Science
ISBN #
10
Wikipedia References
Allan C . Spradling
About:
Born:
1949
Work:
Company:
Johns Hopkins University faculty
Position:Model
Education:
Academic degree:
Member of the United States National Academy of Sciences • Professor
Studied at:University of Chicago • Massachusetts Institute of Technology
Skills & Activities:
Skill:
Technological
Us Patents
US Patent:
6800790, Oct 5, 2004
Filed:
Jul 23, 1999
Appl. No.:
09/358937
Inventors:
Allan C. Spradling - Baltimore MD
Ting Xie - Baltimore MD
Ting Xie - Baltimore MD
Assignee:
Carnegie Institution of Washington - Washington DC
International Classification:
C12P 2100
US Classification:
800 4, 800 13, 800 21, 435325, 435348, 435440, 424 931
Abstract:
The TGF- family of growth factors, particularly the bone morphogenetic protein (BMP)-2/4 homolog decapentaplegic (dpp), are specifically required to maintain germline stem cells and promote their division. Overexpression of dpp blocks germline stem cell differentiation. Mutations in dpp or its receptor saxophone accelerate stem cell loss and retard stem cell division. dpp signaling is directly received by germline stem cells, and thus dpp signaling helps define a niche that controls germline stem cell proliferation.
US Patent:
7402665, Jul 22, 2008
Filed:
Jul 31, 2003
Appl. No.:
10/630660
Inventors:
Allan C. Spradling - Baltimore MD, US
Dianne Stewart Williams - Baltimore MD, US
Alexei V. Tulin - Baltimore MD, US
Dianne Stewart Williams - Baltimore MD, US
Alexei V. Tulin - Baltimore MD, US
Assignee:
Carnegie Institution of Washington - Washington DC
International Classification:
C07H 21/04
C12N 9/12
C12N 9/12
US Classification:
536 234, 435194, 536 235, 536 231
Abstract:
Poly(ADP)-ribose polymerase (PARP) becomes activated at sites of DNA damage and is thought to promote repair by modifying local chromatin proteins and transcription factors. Disclosed is an isoform of PARP, PARP-e, which lacks enzymatic function and which is encoded by a gene having a novel structure. Also disclosed are methods of modulating chromatin structure resulting in modulation of gene activation, gene repression and chromatin condensation and decondensation.
US Patent:
20040157324, Aug 12, 2004
Filed:
Feb 2, 2004
Appl. No.:
10/768694
Inventors:
Allan Spradling - Baltimore MD, US
Ting Xie - Baltimore MD, US
Ting Xie - Baltimore MD, US
Assignee:
Carnegie Institution of Washington
International Classification:
C12N005/06
US Classification:
435/348000
Abstract:
The TGF- family of growth factors, particularly the bone morphogenetic protein (BMP)-2/4 homolog decapentaplegic (dpp), are specifically required to maintain germline stem cells and promote their division. Overexpression of dpp blocks germline stem cell differentiation. Mutations in dpp or its receptor saxophone accelerate stem cell loss and retard stem cell division. dpp signaling is directly received by germline stem cells, and thus dpp signaling helps define a niche that controls germline stem cell proliferation.
US Patent:
46703888, Jun 2, 1987
Filed:
Dec 30, 1982
Appl. No.:
6/454518
Inventors:
Gerald M. Rubin - Baltimore MD
Allan C. Spradling - Baltimore MD
Allan C. Spradling - Baltimore MD
Assignee:
Carnegie Institution of Washington - Washington DC
International Classification:
C12N 1500
C12N 100
C12N 100
US Classification:
4351723
Abstract:
A method for incorporating a desired DNA sequence into the genome of a recipient multi-cellular organism comprising: (1) producing a transposable element of DNA, the element comprising a defined sequence of nucleotide base pairs wherein the defined sequence of nucleotide base pairs comprises at least two sets of target DNA sequences recognizable by transposase and a fragment of DNA, encoding for a structural gene, regulatory gene or other functional DNA, inserted between the sets of target DNA sequences; (2) incorporating the transposable element produced in (1) above into a cell of a recipient multi-cellular organism; and (3) causing the transposable element to be affirmatively inserted into the genome of the recipient multi-cellular organism. The transposable element can additionally become a part of the heritable genome of the recipient multi-cellular organism.