US Patent:
20100240665, Sep 23, 2010
Inventors:
Sue Gail ECKHARDT - Evergreen CO, US
Todd Michael PITTS - Thornton CO, US
Aik Choon TAN - Englewood CO, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO - Denver CO
International Classification:
A61K 31/4985
C12Q 1/68
C12Q 1/48
C12Q 1/32
C12Q 1/42
C12Q 1/00
US Classification:
514249, 435 6, 435 15, 435 26, 435 21, 435 4
Abstract:
The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell expresses certain sensitivity or resistance biomarkers, or genomic classifiers. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate this methodology are also provided.
