Inventors:
John P. Toscano - Glen Arm MD, US
Art Sutton - Baltimore MD, US
Vincent J. Kalish - Annapolis MD, US
Frederick Arthur Brookfield - Abingdon, GB
Stephen Martin Courtney - Abingdon, GB
Lisa Marie Frost - Abingdon, GB
International Classification:
A61K 31/27
C07C 311/51
C07C 311/53
C07D 333/34
C07D 295/185
C07D 307/82
C07C 239/22
C07C 271/08
A61K 31/222
A61K 31/381
A61K 31/495
A61K 31/343
A61K 31/40
A61P 9/00
A61P 9/04
A61P 9/10
A61P 9/12
A61P 35/00
US Classification:
51425501, 560250, 560251, 560 12, 560 13, 549 65, 544390, 549466, 560106, 560 20, 560228, 560227, 560157, 558262, 514507, 514488, 514485, 514445, 514470, 514423
Abstract:
The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.